| publication name | Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines |
|---|---|
| Authors | Ebrahim H. Ghazvini Zadeh, Bahaa El-Dien M. El-Gendy, Alex G. Pop and Alan R. Katritzky |
| year | 2012 |
| keywords | |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | http://pubs.rsc.org/en/content/articlelanding/2012/md/c1md00177a/unauth#!divAbstract |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a–p, and 8f′) and previously unknown N-Cbz-1,2,4-triazine-derived α-amino acids (11a–d, 11d′, 13a,b, and 13a′) were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p.