Staff Members - Benha University
Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines
• 2012
Publication Information
Authors
Ebrahim H. Ghazvini Zadeh, Bahaa El-Dien M. El-Gendy, Alex G. Pop and Alan R. Katritzky
Keywords
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Journal
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Issue
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Pages
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publication.type
International
Paper Link
Open Link
Supplementary Materials
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Abstract
Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a–p, and 8f′) and previously unknown N-Cbz-1,2,4-triazine-derived α-amino acids (11a–d, 11d′, 13a,b, and 13a′) were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p.