Staff Members - Benha University
Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni
• 2023
Publication Information
Authors
Nagwa S. M. Aly1,2,* , Hye-Sook Kim2 , Maysa A. Eraky1
, Asmaa A. El Kholy1
, Basma T. Ali1
, Shin-ichi Miyoshi3
,
Rabab E. Omar1
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Schistosomiasis causes significant morbidity and mortality worldwide. This study aimed
to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg
antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred male
Swiss albino mice were divided into 6 groups. Two doses of the vaccine were given at
2-week intervals. All mice were subcutaneously infected with 80±10 Schistosoma mansoni cercariae 2 weeks after the last vaccination dose, after which they were sacrificed 7
weeks post-infection. Parasitological and histopathological studies were conducted to
assess the effect of inoculated antigens (single or combined). The results showed that
the combination of SLAP and SEA (combination group) led to a significant reduction in
worm burden (65.56%) and liver and intestine egg count (59% and 60.59%, respectively). The oogram pattern revealed a reduction in immature and mature eggs (15±0.4 and
10±0.8, respectively) and an increased number of dead eggs in the combination group
(P
to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg
antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred male
Swiss albino mice were divided into 6 groups. Two doses of the vaccine were given at
2-week intervals. All mice were subcutaneously infected with 80±10 Schistosoma mansoni cercariae 2 weeks after the last vaccination dose, after which they were sacrificed 7
weeks post-infection. Parasitological and histopathological studies were conducted to
assess the effect of inoculated antigens (single or combined). The results showed that
the combination of SLAP and SEA (combination group) led to a significant reduction in
worm burden (65.56%) and liver and intestine egg count (59% and 60.59%, respectively). The oogram pattern revealed a reduction in immature and mature eggs (15±0.4 and
10±0.8, respectively) and an increased number of dead eggs in the combination group
(P