Schistosomiasis causes significant morbidity and mortality worldwide. This study aimed
to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg
antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred male
Swiss albino mice were divided into 6 groups. Two doses of the vaccine were given at
2-week intervals. All mice were subcutaneously infected with 80±10 Schistosoma mansoni cercariae 2 weeks after the last vaccination dose, after which they were sacrificed 7
weeks post-infection. Parasitological and histopathological studies were conducted to
assess the effect of inoculated antigens (single or combined). The results showed that
the combination of SLAP and SEA (combination group) led to a significant reduction in
worm burden (65.56%) and liver and intestine egg count (59% and 60.59%, respectively). The oogram pattern revealed a reduction in immature and mature eggs (15±0.4 and
10±0.8, respectively) and an increased number of dead eggs in the combination group
(P