Staff Members - Benha University
Utility of 4-(isatin-3-ylideneamino)benzohydrazide in the synthesis of bioactive N-heterocyclic compounds
Journal of Chemical and Pharmaceutical Research • 2014
Publication Information
Authors
M. M. H. Arief, A. A. Aly, A. A. Khalil and H. I. Mohamed
Keywords
Isatin schiff's bases, benzohydrazide, thiadiazole, pyrazole, antimicrobial activity.
Journal
Journal of Chemical and Pharmaceutical Research
Publisher
Not Available
Volume
6
Issue
2
Pages
327-335
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
4-(Isatin-3-ylideneamino)benzoic acid, was synthesized and converted into 4-(isatin-3-ylideneamino)benzoyl
chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter
compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and
oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. Some of the synthesized
heterocycles were screened against selected microbes to test their antimicrobial activity.
chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter
compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and
oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. Some of the synthesized
heterocycles were screened against selected microbes to test their antimicrobial activity.