أعضاء هيئة التدريس - جامعة بنها
Utility of 4-(isatin-3-ylideneamino)benzohydrazide in the synthesis of bioactive N-heterocyclic compounds
Journal of Chemical and Pharmaceutical Research • 2014
معلومات البحث
المؤلفون
M. M. H. Arief, A. A. Aly, A. A. Khalil and H. I. Mohamed
الكلمات المفتاحية
Isatin schiff's bases, benzohydrazide, thiadiazole, pyrazole, antimicrobial activity.
المجلة العلمية
Journal of Chemical and Pharmaceutical Research
الناشر
Not Available
المجلد
6
العدد
2
الصفحات
327-335
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
4-(Isatin-3-ylideneamino)benzoic acid, was synthesized and converted into 4-(isatin-3-ylideneamino)benzoyl
chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter
compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and
oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. Some of the synthesized
heterocycles were screened against selected microbes to test their antimicrobial activity.
chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter
compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and
oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. Some of the synthesized
heterocycles were screened against selected microbes to test their antimicrobial activity.