Staff Members - Benha University
ENDOTHELIAL NITRIC OXIDE SYNTHASE 4A/B POLYMORPHISM AND ITS INTERACTION WITH G894T VARIANTS IN TYPE 2 DIABETES MELLITUS : PREDICTING THE RISK OF DIABETIC NEPHROPATHY
• 2016
Publication Information
Authors
Azza Abo Senna, 1Jehan H Sabry, 1Mohamed A Al Hindi, 1Hesham A Eissa, 2Abdelmonem Ahmed, and Basma M Salem.
Keywords
eNOS polymorphism,
Type 2 DM,
Diabetic nephropathy.
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
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Abstract
Background:
nitric oxide synthase (eNOS) and it regulates endothelial function. The presence of
might further complicate endothelial dysfunction and nephropathy through reduced production of NO.
This study
polymorphisms on the risk of diabetic nephr
Patients and Methods:
healthy subjects serving as a control group. All candidates were genotyped
polymorphism using PCR
Results
control for eNOS G894T and (4a/b) Polymorphisms
differences
with p value
and macroalbuminuria when compared with controls but the presence of
effect.
Conclusion:
4a or 894T allele, the risk of developing DN increased significantly. However, the presence of both
alleles together was
nitric oxide synthase (eNOS) and it regulates endothelial function. The presence of
might further complicate endothelial dysfunction and nephropathy through reduced production of NO.
This study
polymorphisms on the risk of diabetic nephr
Patients and Methods:
healthy subjects serving as a control group. All candidates were genotyped
polymorphism using PCR
Results
control for eNOS G894T and (4a/b) Polymorphisms
differences
with p value
and macroalbuminuria when compared with controls but the presence of
effect.
Conclusion:
4a or 894T allele, the risk of developing DN increased significantly. However, the presence of both
alleles together was