| publication name | ENDOTHELIAL NITRIC OXIDE SYNTHASE 4A/B POLYMORPHISM AND ITS INTERACTION WITH G894T VARIANTS IN TYPE 2 DIABETES MELLITUS : PREDICTING THE RISK OF DIABETIC NEPHROPATHY |
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| Authors | Azza Abo Senna, 1Jehan H Sabry, 1Mohamed A Al Hindi, 1Hesham A Eissa, 2Abdelmonem Ahmed, and Basma M Salem. |
| year | 2016 |
| keywords | eNOS polymorphism, Type 2 DM, Diabetic nephropathy. |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: nitric oxide synthase (eNOS) and it regulates endothelial function. The presence of might further complicate endothelial dysfunction and nephropathy through reduced production of NO. This study polymorphisms on the risk of diabetic nephr Patients and Methods: healthy subjects serving as a control group. All candidates were genotyped polymorphism using PCR Results control for eNOS G894T and (4a/b) Polymorphisms differences with p value and macroalbuminuria when compared with controls but the presence of effect. Conclusion: 4a or 894T allele, the risk of developing DN increased significantly. However, the presence of both alleles together was