Staff Members - Benha University
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA
Cancer genetics and cytogenetics • 2010
Publication Information
Authors
Inas A Ahmed, Carsten M Pusch, Thanaa Hamed, Hamed Rashad, Amal Idris, Amal Abou El-Fadle, Nikolaus Blin
Keywords
Not Available
Journal
Cancer genetics and cytogenetics
Publisher
Elsevier
Volume
199
Issue
2
Pages
96-100
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Novel strategies for early detection of breast cancer, the most common and second most
lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA
methylation has established hypermethylation as one of the most frequent molecular
alterations that may initiate and drive many types of human neoplasia including breast
cancer. Detecting such epigenetic changes in DNA derived not only from tumor tissue, but
also from bodily fluids, may be a promising target for the molecular analysis of cancer.
lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA
methylation has established hypermethylation as one of the most frequent molecular
alterations that may initiate and drive many types of human neoplasia including breast
cancer. Detecting such epigenetic changes in DNA derived not only from tumor tissue, but
also from bodily fluids, may be a promising target for the molecular analysis of cancer.