أعضاء هيئة التدريس - جامعة بنها
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA
Cancer genetics and cytogenetics • 2010
معلومات البحث
المؤلفون
Inas A Ahmed, Carsten M Pusch, Thanaa Hamed, Hamed Rashad, Amal Idris, Amal Abou El-Fadle, Nikolaus Blin
الكلمات المفتاحية
Not Available
المجلة العلمية
Cancer genetics and cytogenetics
الناشر
Elsevier
المجلد
199
العدد
2
الصفحات
96-100
publication.type
International
رابط البحث
Open Link
المواد المرفقة
Not Available
الملخص
Novel strategies for early detection of breast cancer, the most common and second most
lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA
methylation has established hypermethylation as one of the most frequent molecular
alterations that may initiate and drive many types of human neoplasia including breast
cancer. Detecting such epigenetic changes in DNA derived not only from tumor tissue, but
also from bodily fluids, may be a promising target for the molecular analysis of cancer.
lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA
methylation has established hypermethylation as one of the most frequent molecular
alterations that may initiate and drive many types of human neoplasia including breast
cancer. Detecting such epigenetic changes in DNA derived not only from tumor tissue, but
also from bodily fluids, may be a promising target for the molecular analysis of cancer.