Effect of antioxidant of ginger (ZingiberOfficinale) on blood lipids of rats was studied. Forty adult male albino rats weighing from 180 to 190 gwere divided into five groups each of them was eight rats. The experiment was, the first one for three weeks and the second at six weeks.In the first period the normal control group was fed on basal diet, while the other four groups were fed on hyperlipidemic diets supplemented with 0.5,1.5% and 1.5 dried ginger respectively. Results indicated that chemical composition values of ginger were as follows: protein (9.0%) ,ash (7.0%), fiber (3.0%), fat (3.4%) and carbohydrates(67.9%), while total phonic compounds (11.3± 1.6 mg tannic acid / g dry mater ; total flavonoids (1.4± 0.11 mg quercetin/g) and total flavonols (1.1 ± 0.09 mg /g quercetin dry mater). There were significant differences between organs weight and also relative organs weight of rats (liver, kidney, spleen and heart) comparing with untreated group (G2). Significant reduction in plasma levels of total lipids, triglycerides, total cholesterol, LDL-c and VLD-c of rats fed on dried ginger as comparing with (G2). Liver functions (AST, ALT and ALP activities) of rats which fed on ginger were improved as comparing with (G2). Kidney functions results (Serum urea, urea, uric acid and creatinine) showed no significant differences between (G2) and groups other of rats.