Cirrhosis is a pathologic condition characterized by fibrosis of the liver parenchyma and evidence of regenerative activity, resulting in portal Hypertension . Esophageal varices are dangerous complication of liver cirrhosis, once esophageal varices develops it tend to bleed, and consider one of the most commonly reported causes of death in patients of cirrhosis ranging from 10% to 57% (wang et al.,2014). Endoscopic screening for esophageal varices is currently recommended, Repeated endoscopies screening burden to endoscopic unit ability and unpleasant for the patient The aim of this study is to determine the value of non- invasive parameter (right lobe of the liver diameter / serum albumin concentratin ratio) in the prediction of esophageal varices in patient with liver cirrhosis The study was conducted on 50 patients with established liver Cirrhosis with no history of variceal haemorrhage from those attended the outpatient clinic and inpatient admitted to Internal Medicine Department, at Benha University Hospital All patients, after giving their informed consent, they were subjected to following Detailed medical history, Complete clinical examination, Laboratory investigations Abdominal Ultrasound upper gastrointestinal endoscopy The patients were divided according to presence of oesophgeal varices Group A :Included 40 patients with liver cirrhosis and with Oesophageal varices. Group B : Included 10 patients with liver cirrhosis and without Oesophageal varices We made a comparison between the two groups to determine the variables associated with the presence of oesophgeal varices in order to predict the presence of them The study will provide insight into the relationship between clinical, biochemical, hematological and imaging abnormalities and development of clinically significant oesophageal varices The analysis revealed that hypoalbuminemia,Thrombocytopenia, advanced liver disease (worsen child score) and decreased right lobe diameter, were significantly associated with the presence of varices The right liver lobe diameter/s. albumin ratio was significant higher with the presence of varices The right liver lobe diameter/s. albumin ratio was significantly prevalent with the oesophgeal varices In conclusion, Right liver lobe diameter /serum albumin has a significant positive correlation with the oesophgeal varices and consider agood predictor of oesophgeal varices varices