Staff Members - Benha University
Revisiting the management of recurrent implantation failure through freeze-all policy
• 2017
Publication Information
Authors
Yasmin Magdi, M.Sc.,a Ahmed El-Damen, M.Sc.,b Ahmed Mohamed Fathi, M.Sc.,c
Ahmed Mostafa Abdelaziz, M.D.,d Mohamed Abd-Elfatah Youssef, M.D., Ph.D.,e
Ahmed Abd-Elmaged Abd-Allah, M.D.,e Mona Ahmed Elawady, M.D.,f Mohamed Ahmed Ibrahim, M.D.,d
and Yehia
Keywords
Freeze all policy, recurrent implantation failure
Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
To determine whether a freeze-all policy for in vitro human blastocysts improves the ongoing pregnancy rate in patients
with recurrent implantation failure (RIF).
Design: Prospective cohort study.
Setting: Single private center.
Patient(s): A total of 171 women with RIF divided into two groups: freeze-all policy group (n ¼ 81) and fresh embryo transfer (ET)
group (n ¼ 90).
Intervention(s): Freeze-all policy.
Main Outcome Measure(s): Ongoing pregnancy rate.
Result(s): The clinical pregnancy rate (52% vs. 28%; odds ratio [OR] 1.86; 95% confidence interval [CI], 1.29–2.68) and ongoing
pregnancy rate (44% vs. 20%; OR 2.2; 95% CI, 1.04–3.45) were statistically significantly higher in the freeze-all group than the
fresh ET group, respectively. The implantation rate was also statistically significant (freeze-all group 44.2% vs. fresh ET group
15.8%; OR 2.80; 95% CI, 2.00–3.92).
Conclusion(s): The freeze-all policy statistically significantly improved the ongoing pregnancy and implantation rates. Thus, a freezeall
policy is likely to be the new key to helping open the black box of RIF. These findings also are useful for further investigating the
adverse effect of controlled ovarian stimulation on in vitro fertilization outcomes. (Fertil Steril 2017;-:-–-. 2017 by American
Society for Reproductive Medicine.)
with recurrent implantation failure (RIF).
Design: Prospective cohort study.
Setting: Single private center.
Patient(s): A total of 171 women with RIF divided into two groups: freeze-all policy group (n ¼ 81) and fresh embryo transfer (ET)
group (n ¼ 90).
Intervention(s): Freeze-all policy.
Main Outcome Measure(s): Ongoing pregnancy rate.
Result(s): The clinical pregnancy rate (52% vs. 28%; odds ratio [OR] 1.86; 95% confidence interval [CI], 1.29–2.68) and ongoing
pregnancy rate (44% vs. 20%; OR 2.2; 95% CI, 1.04–3.45) were statistically significantly higher in the freeze-all group than the
fresh ET group, respectively. The implantation rate was also statistically significant (freeze-all group 44.2% vs. fresh ET group
15.8%; OR 2.80; 95% CI, 2.00–3.92).
Conclusion(s): The freeze-all policy statistically significantly improved the ongoing pregnancy and implantation rates. Thus, a freezeall
policy is likely to be the new key to helping open the black box of RIF. These findings also are useful for further investigating the
adverse effect of controlled ovarian stimulation on in vitro fertilization outcomes. (Fertil Steril 2017;-:-–-. 2017 by American
Society for Reproductive Medicine.)