This study was carried out on twenty two balady pregnant ewes (3-5 years old) at the last 2-4 weeks of gestation. Twelve animals of them showed signs of pregnancy toxaemia (incoordination, tremors of head and neck and sternal recumbency). Also, there was ketonuria. The other ten ewes were clinically healthy and considered as control group. Blood samples were collected without anticoagulant for preparation of serum. Biochemical analysis of serum from these animals indicated a significant decrease of glucose, calcium, phosphorus, magnesium, sodium, and total proteins. While there was significant increase of total lipids, cholesterol, free fatty acids, ALP, ALT, AST, urea and creatinine.