The aim of the present study is to investigate the histomorphological changes of the skeletal muscle during early larval stages of Nile tilapia with special concern to the hyperplasia, occurring in the skeletal muscles. A total number of 80 Nile tilapia fish Oreochromis niloticus divided into six different agedependent groups were fixed in neutral buffered formalin and examined by light and scanning electron microscope(SEM) .It was found that, the myotomal tissues differentiated and divided into epimeric (epaxial) and hypomeric (hypaxial) part by distinct horizontal septum at 2 days post hatching larvae .Two types of skeletal muscle appear red muscle fiber and white muscle fiber at 3 days post hatching larvae .These findings indicated that hyperplastic growth was increased gradually with significant difference between all stages during early larval stage of Nile tilapia.