| publication name | Hepatoprotective effect of asparagus racemosus in paracetamol inducedhepatotoxicity in rats. |
|---|---|
| Authors | Yakout A. El-Senosiy1; Souad A. Ahmad 2; Ayman S. Farid 3; Wessam E.M. |
| year | 2015 |
| keywords | Paracetamol, Asparagus racemosus, hepatotoxicity, antioxidants. |
| journal | BENHA VETERINARY MEDICAL JOURNAL |
| volume | 28 |
| issue | 1 |
| pages | Not Available |
| publisher | BENHA VETERINARY MEDICAL JOURNAL |
| Local/International | International |
| Paper Link | http://www.bvmj.bu.edu.eg/issues/28-1/15.pdf |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
The Asparagus racemosus was evaluated for its hepatoprotective activities against paracetamol inducedhepatotoxicity in rats. Forty rats were used divided into 2 groups, normal control: Composed from 10rats and Hepatotoxicity induced group composed from 30 rats administrated of paracetamol by dose1gm/kg b. wt. orally. For 10 days, then every 72h. Until the end of experiment time. This groupsubdivided into 3 subgroup: 1-Paracetamol group: 10 rats as control negative. 2-Silymarin treated group:10 rats taken silymarin by dose 100 mg/kg daily P.O. for (15) days (Kumar et al., 2011). 3-Asparagustreated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O.for 15 days. (Kumar et al., 2011and Sara et al., 2013). Paracetamol-induced a significant increase in,aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), withmarked reduction in superoxide dismutase (SOD) and catalase (CAT) activities. Treatment of rats withAsparagus racemosus (500 mg/kg b. wt.) significantly altered serum marker enzymes and antioxidantstatus to near a normal level against paracetamol-treated rats. Such hepatoprotective activities ofAsparagus racemosus were comparable to silymarin administrated (100 mg/kg b. wt. p.o.). The resultsindicate that the hepatoprotective properties of Asparagus racemosus against paracetamol-inducedhepatotoxicity in rats