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Hepatoprotective effect of asparagus racemosus in paracetamol inducedhepatotoxicity in rats.

BENHA VETERINARY MEDICAL JOURNAL • 2015
العودة
معلومات البحث
المؤلفون Yakout A. El-Senosiy1; Souad A. Ahmad 2; Ayman S. Farid 3; Wessam E.M.
الكلمات المفتاحية Paracetamol, Asparagus racemosus, hepatotoxicity, antioxidants.
المجلة العلمية BENHA VETERINARY MEDICAL JOURNAL
الناشر BENHA VETERINARY MEDICAL JOURNAL
المجلد 28
العدد 1
الصفحات Not Available
publication.type International
رابط البحث Open Link
المواد المرفقة Not Available
الملخص
The Asparagus racemosus was evaluated for its hepatoprotective activities against paracetamol inducedhepatotoxicity in rats. Forty rats were used divided into 2 groups, normal control: Composed from 10rats and Hepatotoxicity induced group composed from 30 rats administrated of paracetamol by dose1gm/kg b. wt. orally. For 10 days, then every 72h. Until the end of experiment time. This groupsubdivided into 3 subgroup: 1-Paracetamol group: 10 rats as control negative. 2-Silymarin treated group:10 rats taken silymarin by dose 100 mg/kg daily P.O. for (15) days (Kumar et al., 2011). 3-Asparagustreated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O.for 15 days. (Kumar et al., 2011and Sara et al., 2013). Paracetamol-induced a significant increase in,aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), withmarked reduction in superoxide dismutase (SOD) and catalase (CAT) activities. Treatment of rats withAsparagus racemosus (500 mg/kg b. wt.) significantly altered serum marker enzymes and antioxidantstatus to near a normal level against paracetamol-treated rats. Such hepatoprotective activities ofAsparagus racemosus were comparable to silymarin administrated (100 mg/kg b. wt. p.o.). The resultsindicate that the hepatoprotective properties of Asparagus racemosus against paracetamol-inducedhepatotoxicity in rats