Wheat is the most important crop in Egypt and the imports are large to fill the gap between production and consumption. Biofertilization is highly needed to help increasing the local production. N2 fixers Azospirillum+Azotobacterbacteria, P-dissolver Bacillus megaterium bacteria and K-dissolver B. circulans bacteria were assessed for wheat growth and nutrient uptake in 3 pot experiments (one for each nutrient) in absence or presence of nutrient-rich chicken manure (CM) applied at 10 g kg 1.Increases in plant growth (45- day growth) of up to 50% occurred particularly in presence of CM. Sources of rock phosphate P and rock (feldspar) K were used to provide available P and K with the help of the biofertilizers and along with the organic manure. Soluble sources of N (ammonium sulphate), P (Ca-superphosphate) and K (K-sulphate) were included for comparisons. Practical implications indicate a strong proof that using biofertilizers can contribute to sustainability in boosting wheat production.