Staff Members - Benha University
Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome
• 2022
Publication Information
Authors
Omima M. Abdel Haie1
, Abdel Hamid S. El hamshary1
, Asmaa A. El Falah2
,
Ashraf R. Mohammed3
, Wesam E. Afifi
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: Idiopathic nephrotic syndrome (INS) is a clinical syndrome characterized by massive loss of urinary
protein leading to hypoproteinemia and edema. It is reported that the immune system plays an important role in
pathogenesis and pathophysiology of INS. The moncyte chemotactic protein-1 plays an important role in the
recruitment of monocytes/macrophages into renal tubulointerstitium.
Aim of the study: The aim of our study was planned to measure the urinary level of monocyte chemotactic protein
1(MCP-1) in children with INS during remission and relapse, and predict steroid responsiveness.
Methods: This prospective study included 50 patients with nephrotic syndrome (NS) following up in Pediatric
Nephrology Clinic, Benha University subdivided into 2 groups: group A (cases in remission) & group B (cases in
activity). Also, 20 age and sex matched healthy children have been included as a control group.
Results: We found a significant increase in urinary MCP-1 in INS patients as compared to control group (p <
0.001). Also, our study showed that group B had the highest levels of uMCP-1 followed by group A then control
group (p
protein leading to hypoproteinemia and edema. It is reported that the immune system plays an important role in
pathogenesis and pathophysiology of INS. The moncyte chemotactic protein-1 plays an important role in the
recruitment of monocytes/macrophages into renal tubulointerstitium.
Aim of the study: The aim of our study was planned to measure the urinary level of monocyte chemotactic protein
1(MCP-1) in children with INS during remission and relapse, and predict steroid responsiveness.
Methods: This prospective study included 50 patients with nephrotic syndrome (NS) following up in Pediatric
Nephrology Clinic, Benha University subdivided into 2 groups: group A (cases in remission) & group B (cases in
activity). Also, 20 age and sex matched healthy children have been included as a control group.
Results: We found a significant increase in urinary MCP-1 in INS patients as compared to control group (p <
0.001). Also, our study showed that group B had the highest levels of uMCP-1 followed by group A then control
group (p