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Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID
Benha medical journal • 2021
Publication Information
Authors
Wessam A abdelgail , Randa M Mostafa , Abeer A shoman , Noha I Hussien , Mahmoud M Hassan
Keywords
Ovariectomy, Isoflavone, Cognition, GABA, Glutamate.
Abbreviations: SIF; soy isoflavone, OVX; Ovariectomy, NORT; novel object recognition test, GABA; Gaba amino butyric acid, FSH; Follicle Stimulating Hormone, E2;17β-estradiol.
Journal
Benha medical journal
Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: Menopause is a biological process that can cause various troublesome symptoms such as hot flashes and emotional changes but can also affect cognitive functions. Soy isoflavones (SIF), are natural compounds that gained popularity as an alternative treatment for menopausal symptoms. Aim: The aim of this work was to investigate the effect of isoflavone treatment on memory in ovariectomized female albino rats. Method: 32 female albino rats were divided into 4 groups consisting of 8 rats in each group; sham, Sham+isoflavone, bilateral Ovariectomy (OVX), OVX + isoflavone. After isoflavone treatment, the animals underwent the novel object recognition test (NORT), and their performance was evaluated. at the end of the experiment. Gaba amino butyric acid (GABA) and glutamate were measured in hippocampal tissues and hormonal level of follicle stimulating hormone (FSH) & 17β-estradiol (E2) were measured in serum.
Results: Animals with ovariectomy showed significant increase (P
Results: Animals with ovariectomy showed significant increase (P