Back ground: Psoriasis is one of the most common dermatologic disorders. It is impairs many aspects of individual well-being. Patient education is an integral part of comprehensive chronic disease management. Aim: This study to evaluate the effectiveness of an educational program on self-care practices and functional status among patients with psoriasis. Design: A quasi experimental design will be conducted to achieve the aim of the study. Setting: This study will be conducted in dermatological department at Benha University Hospital and outpatient clinics and Dermatology Hospital at Benha city. Sample: Purposive sample of 43 psoriatic patients admitted to the dermatology department at Benha University Hospital and at dermatology hospital during one year. Tools: Four tools were used in this study; tool (1) Patients’ interview questionnaire; consists of three parts, Part 1: Psoriatic patients' personal data, Part 2: Patients' history, Part 3: Patients' personal habits Tool (II) Psoriasis Patients' Knowledge Questionnaire; consists of two parts, Part 1: knowledge about disease overview, Part 2: knowledge about psoriasis treatment. Tool III: Self-care practices assessment. Tool IV: A Disease-Specific Version of the Euro Quality of life-5 Dimensions-5 Level (EQ-5D-5L). Results: None of the studied patients had satisfactory level of knowledge at pre-program implementation compared to post one month and three month of program. 8.6% of studied patients had correct self-care practices pre-program implementation while as post program improved to 86.0% but after three months declined to 74.4%. There is a negative correlation with statistical significance difference between functional status and total knowledge, total self-care practice at p ≤ 0.05. Conclusion: self-care practices and functional status about psoriasis were improved after implementation of educational program. Recommendations: Conduct educational program to be launched through mass media for public awareness about psoriasis and how to prevent and manage it.