Staff Members - Benha University
Usefulness of serum fetuin-A level as a marker of erectile dysfunction
International Journal of Impotence Research • 2017
Publication Information
Authors
W Kandeed, W El-Shaer, A Sebaey, AA Abou-Taleb, A Fathy, B Elmohamady and AI Mansour
Keywords
Fetuin A; ED;markers
Journal
International Journal of Impotence Research
Publisher
Macmillan Publishers Limited, part of Springer Nature
Volume
29
Issue
Not Available
Pages
189–193
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
This study aimed to evaluate the correlation between serum levels of fetuin-A and the presence and severity of erectile dysfunction
(ED) in Egyptian population. The study was performed on 60 ED patients and 20 age—matched healthy controls. A comprehensive
medical history and complete physical examination were obtained and performed in all participants. ED and its severity were
assessed via International Index of Erectile Function (IIEF-5). Doppler ultrasound, fasting blood glucose level, complete lipid profile,
serum total testosterone (TT) and serum fetuin-A were performed. Our results revealed that there were no statistically significant
differences between the ED group and the controls regarding body mass index, fetal bovine serum, cholesterol, low-density
lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG). However, IIEF-5 and serum TT levels were significantly lower
in ED patients than controls. Regarding serum fetuin-A, our data demonstrated that ED patients had significantly lower serum
fetuin-A levels than controls. In addition, patients with severe ED had lower fetuin-A levels than moderate and mild ED (Po0.001).
Serum fetuin-A levels are positively correlated with cholesterol, LDL, TG and IIEF-5 and negatively correlated with HDL. In
conclusion, serum fetuin-A level could be a potentially useful and sensitive biomarker for ED diagnosis.
(ED) in Egyptian population. The study was performed on 60 ED patients and 20 age—matched healthy controls. A comprehensive
medical history and complete physical examination were obtained and performed in all participants. ED and its severity were
assessed via International Index of Erectile Function (IIEF-5). Doppler ultrasound, fasting blood glucose level, complete lipid profile,
serum total testosterone (TT) and serum fetuin-A were performed. Our results revealed that there were no statistically significant
differences between the ED group and the controls regarding body mass index, fetal bovine serum, cholesterol, low-density
lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG). However, IIEF-5 and serum TT levels were significantly lower
in ED patients than controls. Regarding serum fetuin-A, our data demonstrated that ED patients had significantly lower serum
fetuin-A levels than controls. In addition, patients with severe ED had lower fetuin-A levels than moderate and mild ED (Po0.001).
Serum fetuin-A levels are positively correlated with cholesterol, LDL, TG and IIEF-5 and negatively correlated with HDL. In
conclusion, serum fetuin-A level could be a potentially useful and sensitive biomarker for ED diagnosis.