Introduction: The serum amyloid A1 (SAA1) protein is involved in many pathological diseases. The increased secretion of SAA1 can maintain inflammatory conditions.
Acne vulgaris (AV) is a chronic inflammatory disease of pilosebaceous glands and may
be associated with systemic manifestations.
Aim of the work: This study aimed to evaluate the serum level of SAA1 in patients
with AV.
Subjects and Methods: 120 participants were included in this study: 60 patients with
AV and 60 apparently healthy volunteers as a control group. These participants were
subjected to dermatological examination and assessments of lipid profile, fasting
blood glucose (FBG), and serum SAA1.
Results: Both serum SAA1 and FBG are significantly elevated in patients with AV
than control (p < 0.0001 and p < 0.001, respectively). Furthermore, there are positive correlations between AV severity and SAA1 and FBG (p < 0.001 and p < 0.0001,
respectively).
Conclusions: Serum amyloid A1 is increased in AV, and this elevation may play a role
in the inflammatory milieu of AV.