Background: Overconsumption of High Fat diet (HFD) is one of the major contributors to the current epidemic of cardiomyopathy. Probiotics provide health benefits to the host when ingested in appropriate amounts and it is one of the physiological triggers of Peroxisome Proliferator- Activated Receptor- Gamma (PPAR-γ) Aim: This study aimed to investigate the effect of probiotics on cardiomyopathy induced by HFD in rats and to explore the role of PPAR-γ in this process. Methods: 24 adult Wister albino male rats divided into 4 groups: group I (control group): rats received normal diet, group II(HFD group): rats received HFD for 8 weeks, group III(Probiotics group): rats received normal diet with probiotics& group IV(Probiotics + HFD group): rats received HFD with probiotics .
At the end, ejection fraction (EF), fraction shortening (FS) and left ventricular weight (LVW) were evaluated by Echocardiography and the rats were weighed. The blood samples were taken for biochemical estimation of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C), and cardiac PPAR- γ protein levels Results: HFD caused a significant increase in body weight (BW), LVW, TC, TG, LDL-C with a significant decrease in EF and FS. Probiotics