Background : Cardiac catheterization is a diagnostic and interventional tool available to the cardiologist today. It may lead to several minor and more serious complications which may contribute to morbidity and mortality. The responsibility of the cardiac catheterization team is ensuring good patient care, safety without accidental harm as a result of a health care encounter. Aim : This study was conducted to evaluate nurses', performance regarding safety measures in cardiac catheterization unit. Design : Descriptive research design was used Setting : This study was conducted at cardiac catheterization unit, at Benha University Hospital. Sample : A convenience sample of 40cardiac nurses were involved in the present study. Tools :structured interviewing questionnaire , observational chick list and safety attitude questionnaire sheet were developed to assess the knowledge ,practice and attitude of cardiac nurses. Results :This study revealed that the majority of studied nurses more than half (60%) had unsatisfactory level of total knowledge &practice about safety measures in cardiac catheterization unit. while more than three-quarters(77.5%) of the studied nurses had positive attitude towards safety culture in cardiac catheterization unit Conclusion :knowledge level and practice of cardiac catheterization staff nurses regarding measures increase with years of experience. Recommendations : Strict observation of nurses during work and continuous evaluation of their performance and correction of poor performance is essential