Abstract: Objective: The aim of this study was to assess the efficacy and safety of bipolar plasma kinetic energy for En-Bloc enucleation of NonInvasive Muscle Bladder Cancer (NMIBC). Methods: This study was carried out on 46 patients diagnosed with suspected NMIBC, all patients were achieved using ultrasonography, computed tomography scan, and diagnostic cystoscope, Bi-polar Plasma Kinetic Enucleation of Bladder Tumor (PKEBT). At the end of the procedure, all patients underwent an early installation within the 6 h after Bi-polar PKEBT with a single dose of intravesical mitomycin-c. Follow-up diagnostic cystoscopy was performed at 3, 6, and 12 months. RESULTS: Mean enucleation time was 17±5.4 minutes, mean operative time was 27.9±11.4 minutes, mean hemoglobin deficit was 1.3±0.9 gm/dl, mean postoperative irrigation time was 1.7±2.3 hours and mean hospital stay was 35.4±13 hours. Three procedures were associated with intra-operative bleeding that one of them necessitated blood transfusion. There were no other reported perioperative complications. One month postoperatively, 6 (13%) cases were diagnosed with a residual tumor and had undergone repeat Bi-polar PKEBT. The overall recurrence rate at 12 months' follow-up was 15.2%. Conclusion: Bi-Polar Plasma Kinetic Enucleation technique is an efficient procedure in the management of NMIBC. As it preserves the entire lamina propria and detrusor muscle in well intact specimens with negligible perioperative complications.