The seismotectonic activity in Northeastern Egypt is intimately related to the active tectonic structures (mainly faults) which deform the region and induce intraplate seismicity. The present contribution is a new attempt to integrate structural, remote sensing, and seismic data, and implement a reliable geospatial analysis to investigate and assess the nature of the relation between tectonic structures and seismotectonic activity in the Cairo–Suez district which is an active seismic source zone in Northeastern Egypt. The achieved remote sensing and GIS-based geospatial analysis introduces valuable information on the frequency, orientation, and density of investigated tectonic fault trends. The spatial distribution of earthquakes epicenters which recorded during the period (1997–2016) with magnitude (ML ≥ 3.0) is evidently interrelated with the detected tectonic trends, and normal faulting with subordinate shear component is the most focal mechanisms indicated from the analyzed seismic events. The depth analysis of the studied earthquakes suggests a “hard linkage” between the major rift-boundary faults in the northern Gulf of Suez rift and the tectonic trends in the southern domain of the Cairo–Suez district, and thus indicates seismic activity on relatively deeper crustal levels. Most of the studied earthquakes have occurred on the WNW–ESE to NW–SE oriented faults in predominantly extensional to transtensional stress regime, which indicating theWNWto NW tectonic trend as an active fault trend. The intraplate seismotectonic activity in Northeastern Egypt is highly controlled by two active tectonic boundaries, the Red Sea–Gulf of Suez rift and Aqaba–Dead Sea transform (to the east) and the Pelusium Shear System (PSS, to the west). Any reliable hypothetical model explaining the seismotectonic setting in such region would consider the Cairo–Suez district as a large transfer zone transmitting the “far-field” stresses northwestward to the PSS with an effective mechanismkeeping the within-plateWNW– ESE, NW–SE, and E–W tectonic trends highly prone to rejuvenation and seismic rupture.