diseases that have complex health problems, which affect the quality of life. The aim of this study was to evaluate the effect of self-care management program on quality of life among Acquired Immune Deficiency Syndrome patients. Research design: Quasi-experimental research design was used in this study. Setting: This study was conducted at AIDS Outpatient Clinic in Fever Hospital at Benha City. Sample: Simple random sample of 25 % of attended AIDS patients in last year (2018-2019), the total sample was included (100) patients. Tools: Two tools were used. Tool I): A structured interviewing questionnaire which consisted of three parts a) socio-demographic characteristics, b) AIDS patients` knowledge and c) AIDS patients` self-care reported practices. Tool II): Scale to measure quality of life among AIDS patients. Results; 64% of AIDS patients were males, 39 % of them their aged 35 years or more with mean age was 41.73±11.90, 51% of patients had AIDS for 5years or more and 57% of them during symptomatic stage. 67% the studied AIDS patients had poor knowledge regarding AIDS before program compared with 11% post program. 29% of the studied AIDS patients had satisfactory self-care reported practices before program, which increased to 79% during the post program. 39% of the AIDS patients had poor total scores of quality of life preprogram, which decreased to 16% post program. There were positive statistically significant correlations between AIDS patients` total knowledge scores and AIDS patients ` total self-care reported practices scores, and AIDS patients ` total quality of life scores post program. This study concluded that: Self-care management program succeeded to improve knowledge; self-care reported practices and quality of life among AIDS patients. The study recommended that: Continuous self-care management program for AIDS patients to ncrease their knowledge, self-care practices and improve their quality of life. Keywords: Acquired Immune Deficiency Syndrome Patients, Quality of life and Self-care management program.