Background; Boosting pregnant women knowledge attitude and practice regarding COVID19 are key elements that ensure pregnant women health and safety. Pregnant women’s adherence to control measures is affected by their knowledge, attitudes, and practices (KAP) towards COVID-19. Aim: this study aimed to evaluate the effect of health educational intervention on pregnant women knowledge, attitude and self-protective measures practice toward prevention of COVID 19. Setting: the current study was conducted at six maternal and child health centers affiliated at Kalioubia governorate. Research Design: a quasi-experimental design was used. Sample: simple random sample included 340 pregnant women, recruited as (160) in control group and (180) study group. Tools: three tools were utilized for data collection; A structured interviewing questionnaire, knowledge assessment sheet, COVID 19 related attitude assessment tool, and COVID 19 preventive measures practice assessment. Results: the present study revealed a highly statistical significant improvement of knowledge attitude and practice between subjects at both study and control group. In addition study group subjects indicated high satisfaction level regarding the study guideline. Conclusion: heath educational guideline is effectively improving pregnant women knowledge, attitude and self-protective measures practice regarding prevention of COVID 19.