Staff Members - Benha University
Clinical Implications for Vascular Endothelial Growth Factor Levels among Egyptians with Pulmonary Tuberculosis
Life Science Journal 2013;10(1) • 2013
Publication Information
Authors
Magdy Omar1, Tawfik ElAdl2, Samir Abdullah 2 , Hossam Hamza1, Tawfik ElAdl2 and Mostafa Neamatallah3
Chest1 & Internal Medicine2Departments, Benha University; Medical Biochemistry Department3, Mansoura
University; Egypt
Keywords
Vascular endothelial growth factor,TB,Chemotherapy.
Journal
Life Science Journal 2013;10(1)
Publisher
Tawfik ElAdl
Volume
10
Issue
1
Pages
6
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Abstract: Introduction: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. Intense
angiogenesis has been found in active pulmonary tuberculosis. VEGF role in tuberculosis (TB) has not been fully
elucidated. Aim: This study aimed to measure serum VEGF levels in active pulmonary tuberculosis and changes
following chemotherapy. Subjects and Methods: Twenty five consecutive patients with active pulmonary
tuberculosis and 15 healthy control subjects were enrolled in this prospective randomized controlled study. Complete
medical history, full clinical examination, complete blood examination, erythrocyte sedimentation rate, liver function
tests, kidney function tests, fasting blood sugar, radiological examination by plain X ray chest, tuberculin skin test by
Mantoux method, sputum for acidfast bacilli by Zeil Neilsen stain and estimation of serum VEGF before treatment, 3
months and 6 months after treatment. Results: There was no statistical significant difference (p value >0.05)
between patients and control group regarding age in years (with a mean of 36.75 8.95 for patients and 26.24.4 for
control group) and smoking index in packs/year (with a mean of 239.65 215.40 for patients and 190.6 115.2 for
control group). There was a highly statistical significant difference(p value
angiogenesis has been found in active pulmonary tuberculosis. VEGF role in tuberculosis (TB) has not been fully
elucidated. Aim: This study aimed to measure serum VEGF levels in active pulmonary tuberculosis and changes
following chemotherapy. Subjects and Methods: Twenty five consecutive patients with active pulmonary
tuberculosis and 15 healthy control subjects were enrolled in this prospective randomized controlled study. Complete
medical history, full clinical examination, complete blood examination, erythrocyte sedimentation rate, liver function
tests, kidney function tests, fasting blood sugar, radiological examination by plain X ray chest, tuberculin skin test by
Mantoux method, sputum for acidfast bacilli by Zeil Neilsen stain and estimation of serum VEGF before treatment, 3
months and 6 months after treatment. Results: There was no statistical significant difference (p value >0.05)
between patients and control group regarding age in years (with a mean of 36.75 8.95 for patients and 26.24.4 for
control group) and smoking index in packs/year (with a mean of 239.65 215.40 for patients and 190.6 115.2 for
control group). There was a highly statistical significant difference(p value