Background Depression often occurs in patients with chronic obstructive pulmonary disease (COPD). In stable COPD, the prevalence of clinical depression ranges between 10 and 42%. The risk of depression is higher in patients with severe COPD, compared with control participants, reaching up to 62%, in oxygen-dependent patients. Aim The aim of this work was to study the prevalence of depression in COPD patients. Patients and methods The present study was carried out on 100 male COPD patients and 10 female COPD patients admitted to Mansoura Chest Hospital and the chest department of Benha University Hospital during the period from 2014 to 2016. All participants were submitted to Beck’s depression Inventory questionnaire. Results The degree of depression assessed by Beck’s score increased significantly with the degree of COPD, use of long- term oxygen therapy, and low BMI. Conclusion The prevalence and severity of depression increase with increasing severity of COPD