Staff Members - Benha University
Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease
Egyptian Journal of Chest Diseases and Tuberculosis • 2014
Publication Information
Authors
Ahmed A. Yousef a,b, Mahmoud M. Alsalahy a, Mohammad A. Almahdy a,
Tarek S. Essawy a,*, Khalid M. Belal b
Keywords
COPD;
Granzyme B;
Smokers
Journal
Egyptian Journal of Chest Diseases and Tuberculosis
Publisher
Not Available
Volume
63
Issue
Not Available
Pages
815-819
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Abstract Background: Inflammation of the airways is present in COPD with increased number of
inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis
in which secreted molecules such as granzymes form pores in the membrane of target cells; and
apoptosis. Granzyme B has the strongest apoptotic activity of all granzymes.
Aim of this work: Aim of this work was to study the relation between Granzyme B, tobacco
smoking and chronic obstructive pulmonary disease.
Methods: The study included 40 clinically stable COPD patients classified according to GOLD
(2013) criteria into two groups; moderate (GOLD II) and severe (GOLD III) plus 40 apparently
healthy control subjects (20 smokers and 20 nonsmokers). Pulmonary function results and serum
levels of Granzyme B (measured by ELISA) were recorded.
Results: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.
Conclusion: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.
inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis
in which secreted molecules such as granzymes form pores in the membrane of target cells; and
apoptosis. Granzyme B has the strongest apoptotic activity of all granzymes.
Aim of this work: Aim of this work was to study the relation between Granzyme B, tobacco
smoking and chronic obstructive pulmonary disease.
Methods: The study included 40 clinically stable COPD patients classified according to GOLD
(2013) criteria into two groups; moderate (GOLD II) and severe (GOLD III) plus 40 apparently
healthy control subjects (20 smokers and 20 nonsmokers). Pulmonary function results and serum
levels of Granzyme B (measured by ELISA) were recorded.
Results: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.
Conclusion: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.