To evaluate the effect of timolol 0.1% gel and latanoprost 0.005% on myopic regression after myopic LASIK surgery in comparison to artificial tears as placebo. The study included 90 patients with mean age of 25.7±5.7 years; 12 patients had bilateral LASIK and both eyes were included in the study. A11 patients underwent complete ophthahnologic examination for determination of uncorrected and corrected distant visual acuity (UDVA and CDVA), intraocular pressure (IOP), Sohrimer test, central corneal pachymetry and corneal topography.
These parameters were evaluated at time of inclusion and 3-monthly for 12 months. The percentage of change at the 12th month in comparison to the baseline measures, was calculated for assurance of randomization and accurate evaluation of outcome. Patients were randomly allocated into 3 equal groups:
Control group received artificial tears; Timolol group received timolol maleate 0.1% gel once daily and Prostaglandin (PG) group received latanoprost 0.005% eye drops once daily. Topical therapy significantly improved UCDVA and CDVA at the end of follow-up period compared to control group and to their respective baseline measures with significarrtly higher percentage of improvement in timolol group compared to PG group. Control eyes showed non-significant deterioration of spherical error evaluation and extent of asilgmatism at the end of follow-up compared to baseline measures, while both modalities of topical therapy significantly improved it compared to their respective measures and to control group.