Staff Members - Benha University
The Role of Regulatory T Cells in Preeclampsia
THE EGYPTIAN JOURNAL OF IMMUNOLOGY • 2014
Publication Information
Authors
1Neveen A Abedel Hafeez, 1Mona El-Toukhy Fouda, 1Eman R Abdel
Gawad, 2Tamer Assar, 1Amira I Mansour
Keywords
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Journal
THE EGYPTIAN JOURNAL OF IMMUNOLOGY
Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Preeclampsia is a multisystem disorder of unknown cause that is unique to human pregnancy affecting
about 7-10% of pregnant women. CD4+CD25bright regulatory T (Treg) cells have been identified as a principle
regulator of tolerance during pregnancy. The aim of this study was to demonstrate the change of peripheral
CD4+CD25bright regulatory T lymphocytes in normal pregnancy and preeclampsia, and to explore its role in
the pathogenesis of preeclampsia. We determined CD4+CD25bright Treg cells in the peripheral blood using
flow cytometry and forkhead box P3 (FoxP3+) cells at the peripheral blood using real time PCR. 30
preeclamptic cases (group 1), 10 normal pregnancy subjects (group 2) and 10 non-pregnant healthy controls
(group 3) were included. There was a highly significant decrease as regards Treg count and percentage in
preeclamptic cases compared to normal pregnancy subjects (P
about 7-10% of pregnant women. CD4+CD25bright regulatory T (Treg) cells have been identified as a principle
regulator of tolerance during pregnancy. The aim of this study was to demonstrate the change of peripheral
CD4+CD25bright regulatory T lymphocytes in normal pregnancy and preeclampsia, and to explore its role in
the pathogenesis of preeclampsia. We determined CD4+CD25bright Treg cells in the peripheral blood using
flow cytometry and forkhead box P3 (FoxP3+) cells at the peripheral blood using real time PCR. 30
preeclamptic cases (group 1), 10 normal pregnancy subjects (group 2) and 10 non-pregnant healthy controls
(group 3) were included. There was a highly significant decrease as regards Treg count and percentage in
preeclamptic cases compared to normal pregnancy subjects (P