Nicotine tartrate affects the heart and aortic wall of the developing rats , during gestation and postnatal periods . Therefore, exposure to inhaled nicotine tartrate ,either by active or passive smoking ,must be restricted , especially during pregnancy and lactation .In addition , increasing awareness of its hazards is recommended . Vitamin C is a known chelating agent with non-enzymatic antioxidant features , was widely reported to have the ability to protect cells from oxidative stress in nicotine-exposed rats . So , administration of combined nicotine and ascorbic acid , minimize the harmfull effect of nicotine tartrate on developing heart &aorta . . 161