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EFFECT OF II{ATERNAL ADMINISTRATION OF SODIUM VALPROATE ON THE SKELETAL DEIELOPMENT OF RAT EMBRYOS
Benha l{. J. • 1998
Publication Information
Authors
Talaat M. Mohamed MD, Ibrahim S. EL_Gendy MD*
and Nageh A. ELMahdy MD**
Keywords
Not Available
Journal
Benha l{. J.
Publisher
Not Available
Volume
15
Issue
1
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Fourtg pregnant adurtfemate arbtno rats u)ere used. in this studq . sodium
ualproate administered" orailg to pregnant rats at a dose oJ 4oo mg /
kg /dag on dag 1 to is oJ gestation . AIL anim..b were ktlled. orue d_ag be-
Jore birth The number oJ resorptions, Jetal suruiuars, Jetal ,serghts"
crown-ntmp Lengttrs and maternal bodg tueight gains were d-eterminedand
tlrc Jetuses LDere examined,J-or external, intemal and. skeletcil malformations
. There tuere instgni.f.cant changes in resorption a_nd, suruiual
rates and Jetal bodg tueights significant increase tn m,.terr...l bod.g
weight gain and significant shortening oJ the croun-rLLmp tength LDere recorded
. A higll incidence oJ skeletal abnorrnaliiles as short neck, sprna
bt-fi-da' absence oJ angLe oJ marudible and- absence oJ ossqfic centres in
Iimbs r-uas obserued". Thus , The tLse oJ sodtum uarproate tn pregnancg cts
an antiepttepttc mag be assocrat ed. tutth an increase in the tncidence oJ Je- tal mct"lJormation and toxic effects. rt us fhus uery important to protect the
Jetus Jrom sodium ualproate exposure.
ualproate administered" orailg to pregnant rats at a dose oJ 4oo mg /
kg /dag on dag 1 to is oJ gestation . AIL anim..b were ktlled. orue d_ag be-
Jore birth The number oJ resorptions, Jetal suruiuars, Jetal ,serghts"
crown-ntmp Lengttrs and maternal bodg tueight gains were d-eterminedand
tlrc Jetuses LDere examined,J-or external, intemal and. skeletcil malformations
. There tuere instgni.f.cant changes in resorption a_nd, suruiual
rates and Jetal bodg tueights significant increase tn m,.terr...l bod.g
weight gain and significant shortening oJ the croun-rLLmp tength LDere recorded
. A higll incidence oJ skeletal abnorrnaliiles as short neck, sprna
bt-fi-da' absence oJ angLe oJ marudible and- absence oJ ossqfic centres in
Iimbs r-uas obserued". Thus , The tLse oJ sodtum uarproate tn pregnancg cts
an antiepttepttc mag be assocrat ed. tutth an increase in the tncidence oJ Je- tal mct"lJormation and toxic effects. rt us fhus uery important to protect the
Jetus Jrom sodium ualproate exposure.