Acetamiprid and dinotefuran are a new generation from neonicotinoid insecticides and highly active to protect the various vegetable crops, by controlling mites and insect pests. The rate of disappearance of acetamiprid and dinotefuran residues from tomato and cucumber fruits at a recommended dose was investigated. Under field conditions, the half-life values of acetamiprid were 1.04 and 1.18 days on/in tomato and cucumber fruits and 1.72 and 3.18 days for dinotefuran, respectively. Determined residues of dinotefuran on/in tomato and cucumber fruits were at level below the maximum residue limits (MRL), one hour after application, so that the tomato and cucumber fruits could be used safely at any time after application. Whereas, the residues of acetamiprid reached to the acceptable maximum residue limits in three days post treatment. Residues of acetamiprid and dinotefuran were undetectable on/in tomato and cucumber fruits 15 days after application. It was also concluded, that the loss rate of both insecticides was varied between tomato and cucumber fruits.