| publication name | The Preferential Therapeutic Potential of Chlorella vulgaris against Aflatoxin-Induced Hepatic Injury in Quail |
|---|---|
| Authors | Sawsan S. Elbasuni, Samar S. Ibrahim, Rasha Elsabagh , Mai O. Nada, Mona A. Elshemy, Ayman K. Ismail, Heba M. Mansour , Heba I. Ghamry , Samah F. Ibrahim ,* , Ilhaam Alsaati, Ahmed Abdeen and Alshaimaa M. Said |
| year | 2022 |
| keywords | Chlorellavulgaris;mycotoxins;oxidativestress;inflammatorycytokines;residues;meatquality. |
| journal | Toxins |
| volume | 14 |
| issue | Not Available |
| pages | 843-858 |
| publisher | MDPI |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Aflatoxins(AFs)arethemostdetrimentalmycotoxin,potentiallyhazardoustoanimalsand humans. AFs in food threaten the health of consumers and cause liver cancer. Therefore, a safe, efficient,andfriendlyapproachisattributedtothecontrolofaflatoxicosis. Therefore,thisstudyaimed toevaluatetheimpactsofChlorellavulgaris(CLV)onhepaticaflatoxicosis,aflatoxinresidues,andmeat quality in quails. Quails were allocated into a control group; the CLV group received CLV (1 g/kg diet);theAFgroupreceivedanAF-contaminateddiet(50ppb);andtheAF+CLVgroupreceivedboth treatments. TheresultsrevealedthatAFdecreasedthegrowthperformanceandcausedahepaticinjury, exhibited as an increase in liver enzymes and disrupted lipid metabolism. In addition, AF induced oxidativestress,exhibitedbyadramaticincreaseinthemalondialdehyde(MDA)levelanddecreases inglutathione(GSH)level,superoxidedismutase(SOD),andglutathioneperoxidase(GPx)activities. Significantup-regulationintheinflammatorycytokine(TNF-α,IL-1β,andIL-6)mRNAexpressionwas alsodocumented. Moreover,aflatoxinresiduesweredetectedintheliverandmeatwithanelevation offat%alongsideadecreaseinmeatprotein%. Ontheotherhand,CLVsupplementationameliorated AF-inducedoxidativestressandinflammatoryconditioninadditiontoimprovingthenutritionalvalue ofmeatandsignificantlyreducingAFresidues. CLVmitigatedAF-inducedhepaticdamage,decreased growthperformance,andloweredmeatqualityviaitsantioxidantandnutritionalconstituents.