Background: The rates of cesarean section have increased significantly in recent decades. Postpartum period is accompanied by significant changes in women's quality of life. These alterations can affect the health of mothers and baby. Considering the importance of postnatal quality of life and its different contributing factors, this study aimed to study the effect of utilization of self care guideline to promote quality of life among women undergoing cesarean Section. Design: An intervention (Quasi-Experimental) study was adopted. Setting: The study was conducted at postpartum unit of Maternity department in Fayoum University Hospital. Sample: A purposive sample was used which included 120 mother in postpartum department after cesarean section delivery. They were divided randomly into two groups: the study group which recieved a self- care guideline while the control group received the routine care. Four tools were used for data collection (A Structured interviewing questionnaire, Short Form questionnaire included 35 items to assess women's quality of life, Self- Care diary scale and women's satisfaction" likert scale). Results: showed that self- care guideline has apositive effect on improving the quality of life among women undergoing cesarean Section. Conclusion: The results of the present can be used as a self care guideline to positively enhance women's quality of life after cesarean section delivery. The study recommended the importance of utilizing self care guideline as a part of routine care for postpartum women in all Maternity hospital.