Systemic Lupus Erythematosus (SLE) disease and disease-related consequences as well as treatment-related adverse events have a significant negative effect on life expectancy and quality of life of SLE clients. The study aimed to evaluate the effect of health education based intervention on self-care among systemic lupus erythematosus clients. Design: A quasi experimental design was used. Setting: The study was conducted in Rheumatology Outpatients’ clinic of Benha Teaching Hospital. Sample: A Convenient sample of systemic lupus erythematosus clients was recruited. There were 60 clients. Tools: I- structured interviewing questionnaire to determine demographic characteristics of SLE clients, disease characteristics. II- Systemic Lupus Erythematosus Assessment Tool to assess client's knowledge about SLE and clients’ practices about self-care. III- Lupus Patient Reported Outcomes (lupus PRO). Results: Showed that, the mean age of studied clients was 28.76±5.98, 90% were female, 40% had the disease from 1 to