Staff Members - Benha University
Genetic Expression of High Mobility Group Box 1 in Neonatal Sepsis
Benha Medical Journal • 2022
Publication Information
Authors
Omima M. Abdel Haie, Mona A. Elbeshery, Shuzan A. Mohammed, Salwa S. Husein, NeveenT. Abed
Keywords
neonatal sepsis, high mobility group box 1, HMGB1, real-time PCR, gene expression
Journal
Benha Medical Journal
Publisher
Faculty of Medicine - Benha University
Volume
39
Issue
3
Pages
971-985
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: High-mobility group box 1 (HMGB1) has important
role in a variety of diseases, including neonatal sepsis (NS). The aim of this study is to evaluate the clinical importance of HMGB1 genetic expression in NS demonstrating its diagnostic value and detecting the effect of its genetic expression on the disease outcome.
Patients and
Method: This study was carried out on 100 neonates; 28 neonates with clinical sepsis and had positive blood cultures (confirmed), 22
neonates with clinical sepsis but had negative blood cultures
(suspected) and 50 healthy non-infected newborns age and sex
matched as controls.
Results: Expression of HMGB1 in newborns with confirmed NS and those with suspected NS were higher than healthy controls. Also, it was higher in newborns with confirmed NS than those with suspected NS. The sensitivity and specificity of the diagnostic value of HGMB1 were higher than that of C-reactive protein (CRP) and hematological score (H score). Assessment of the HMGB1 for prognosis of the disease was evaluated by univariate analysis (p=
role in a variety of diseases, including neonatal sepsis (NS). The aim of this study is to evaluate the clinical importance of HMGB1 genetic expression in NS demonstrating its diagnostic value and detecting the effect of its genetic expression on the disease outcome.
Patients and
Method: This study was carried out on 100 neonates; 28 neonates with clinical sepsis and had positive blood cultures (confirmed), 22
neonates with clinical sepsis but had negative blood cultures
(suspected) and 50 healthy non-infected newborns age and sex
matched as controls.
Results: Expression of HMGB1 in newborns with confirmed NS and those with suspected NS were higher than healthy controls. Also, it was higher in newborns with confirmed NS than those with suspected NS. The sensitivity and specificity of the diagnostic value of HGMB1 were higher than that of C-reactive protein (CRP) and hematological score (H score). Assessment of the HMGB1 for prognosis of the disease was evaluated by univariate analysis (p=