Staff Members - Benha University
STAT4 Gene Polymorphism in Children with Type-1 Autoimmune Hepatitis
Benha Journal of Applied Sciences (BJAS) • 2021
Publication Information
Authors
Ola G. Behairy, Nazih M.Alnady, Shuzan A.Mohammedand Walaa A.Ibrahim
Keywords
Autoimmune, Hepatitis, Signal transducer and activator of transcription 4.
Journal
Benha Journal of Applied Sciences (BJAS)
Publisher
Benha University
Volume
6
Issue
3 (Part 1)
Pages
43-52
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
BACKGROUND: The signal transducer and activator of the
transcription 4 (STAT4) gene plays an important role in macrophages, dendritic cells, activated peripheral blood monocytes, and Th1- dependent liver injury.
AIM: To assess the association of signal transducer and activator
of transcription (STAT4) single gene polymorphisms (SNPs)
(rs7574865, rs7582694) with type-1 autoimmune hepatitis (AIH) in
Egyptian children.
MATERIALS AND METHODS: 125 children diagnosed as AIH
type-1and 125 control healthy children were included for genotyping of STAT4 SNPs (rs7574865 and rs7582694).
RESULTS: STAT4 (rs7574865) GT and TT genotypes increased
the risk of AIH type-1 development by 2 and 4 folds regarding the
GG genotype (p < 0.019, 0.001 respectively). T allele individuals
had about 2.5 folds increased risk of the disease compared to those with G allele (p < 0.001). STAT4 (rs7582694) GC and CC genotypes increased the risk of AIH type-1 by 1.76 and 3.8 folds regarding the GG genotype (p < 0.037, 0.015 respectively). The C allele had about 1.88 folds increased risk of AIH type-1 development than those with the G allele (p = 0.002). Dominant model of either SNPs and the recessive model of rs7574865 only are significant predictors of AIH type-1.
CONCLUSION: Minor alleles of both STAT4 SNPs (rs7574865
T allele, rs7582694 C allele) are associated with an increased risk of type-1 AIH. The disease could be predicted by the dominant model of either SNPs and by the recessive model of rs7574865.
transcription 4 (STAT4) gene plays an important role in macrophages, dendritic cells, activated peripheral blood monocytes, and Th1- dependent liver injury.
AIM: To assess the association of signal transducer and activator
of transcription (STAT4) single gene polymorphisms (SNPs)
(rs7574865, rs7582694) with type-1 autoimmune hepatitis (AIH) in
Egyptian children.
MATERIALS AND METHODS: 125 children diagnosed as AIH
type-1and 125 control healthy children were included for genotyping of STAT4 SNPs (rs7574865 and rs7582694).
RESULTS: STAT4 (rs7574865) GT and TT genotypes increased
the risk of AIH type-1 development by 2 and 4 folds regarding the
GG genotype (p < 0.019, 0.001 respectively). T allele individuals
had about 2.5 folds increased risk of the disease compared to those with G allele (p < 0.001). STAT4 (rs7582694) GC and CC genotypes increased the risk of AIH type-1 by 1.76 and 3.8 folds regarding the GG genotype (p < 0.037, 0.015 respectively). The C allele had about 1.88 folds increased risk of AIH type-1 development than those with the G allele (p = 0.002). Dominant model of either SNPs and the recessive model of rs7574865 only are significant predictors of AIH type-1.
CONCLUSION: Minor alleles of both STAT4 SNPs (rs7574865
T allele, rs7582694 C allele) are associated with an increased risk of type-1 AIH. The disease could be predicted by the dominant model of either SNPs and by the recessive model of rs7574865.