Staff Members - Benha University
Measurement of serum trace elements levels in patients with juvenile idiopathic arthritis
Egyptian Rheumatology & Rehabilitation • 2016
Publication Information
Authors
Soliman A. Yasser, Nashwa I. Hashaad, Ali M. Shouzan,Hala A. El Nouty
Keywords
juvenile idiopathic arthritis, serum, trace elements
Journal
Egyptian Rheumatology & Rehabilitation
Publisher
Wolters Kluwer ‑ Medknow
Volume
43
Issue
2
Pages
59–66
publication.type
International
Paper Link
Open Link
Supplementary Materials
Shuzan Ali Mohammed Ali_Soliman2017_Article_ErratumMeasurementOfSerumTrace.pdf
Abstract
Aim
This study was designed to assess the serum levels boron (B), copper (Cu), and zinc (Zn) in patients with juvenile idiopathic arthritis (JIA), and to evaluate their relationships with the disease activity parameters.
Patients and methods
This study was conducted on 30 children with JIA and 20 apparently healthy children. Patients were subjected to a thorough history‑taking, clinical examination, plain radiography of both hands, and laboratory investigations including erythrocyte sedimentation rate, C‑reactive protein, rheumatoid factor, and antinuclear antibodies. Disease activity was measured using
the Juvenile arthritis disease activity score 27 (JADAS‑27 score). Serum B, Cu, and Zn levels were also measured.
Results
The mean serum B level was highly statistically significantly lower in the JIA patients’ group than that in the control group. The mean serum Cu level was highly statistically significantly higher in the JIA patients’ group than that in the control group. Finally, the mean serum Zn level was statistically insignificantly lower in the JIA patients group than that in the control group.
There were significant negative correlations between serum B concentrations and tender joint count (TJC). There were significant positive correlations between serum Cu concentrations and TJC, erythrocyte sedimentation rate, and JADAS‑27. There were significant negative correlations between serum Zn concentrations and TJC and JADAS‑27.
Conclusion
B serum level may play a role in the pathophysiology of JIA and its severity. Serum levels of B, Cu, and Zn seem to be of fundamental importance in the assessment of a JIA patient.
This study was designed to assess the serum levels boron (B), copper (Cu), and zinc (Zn) in patients with juvenile idiopathic arthritis (JIA), and to evaluate their relationships with the disease activity parameters.
Patients and methods
This study was conducted on 30 children with JIA and 20 apparently healthy children. Patients were subjected to a thorough history‑taking, clinical examination, plain radiography of both hands, and laboratory investigations including erythrocyte sedimentation rate, C‑reactive protein, rheumatoid factor, and antinuclear antibodies. Disease activity was measured using
the Juvenile arthritis disease activity score 27 (JADAS‑27 score). Serum B, Cu, and Zn levels were also measured.
Results
The mean serum B level was highly statistically significantly lower in the JIA patients’ group than that in the control group. The mean serum Cu level was highly statistically significantly higher in the JIA patients’ group than that in the control group. Finally, the mean serum Zn level was statistically insignificantly lower in the JIA patients group than that in the control group.
There were significant negative correlations between serum B concentrations and tender joint count (TJC). There were significant positive correlations between serum Cu concentrations and TJC, erythrocyte sedimentation rate, and JADAS‑27. There were significant negative correlations between serum Zn concentrations and TJC and JADAS‑27.
Conclusion
B serum level may play a role in the pathophysiology of JIA and its severity. Serum levels of B, Cu, and Zn seem to be of fundamental importance in the assessment of a JIA patient.