Staff Members - Benha University
Thrombophilic gene mutations in women with repeated spontaneous miscarriage.
Genetic Testing and Molecular Biomarkers • 2010
Publication Information
Authors
Mohamed MA, El Moaty MA, El Kholy AF, Mohamed SA, Ali AI.
Keywords
Not Available
Journal
Genetic Testing and Molecular Biomarkers
Publisher
Mary Ann Liebert, Inc.
Volume
14
Issue
5
Pages
593-7
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
AIM:
One of the main problems concerning repeated spontaneous miscarriage (RSM) is the etiological diagnosis. The relation of thrombophilia to RSM is a matter of debate. In this case-control study, we determined the percentages of three thrombophilic mutations (factor V leiden, prothrombin, and methylenetetrahydrofolate reductase) amongst 20 cases with RSM and 20 control normal parous women.
RESULTS:
There were high statistically significant increases in the number of cases with factor V, prothrombin, and methylenetetrahydrofolate reductase gene mutations compared with normal control and the percentage of multiple gene mutations was higher than single gene mutation.
CONCLUSION:
The prevalence of thrombophilic mutations is higher in cases of RSM than control.
One of the main problems concerning repeated spontaneous miscarriage (RSM) is the etiological diagnosis. The relation of thrombophilia to RSM is a matter of debate. In this case-control study, we determined the percentages of three thrombophilic mutations (factor V leiden, prothrombin, and methylenetetrahydrofolate reductase) amongst 20 cases with RSM and 20 control normal parous women.
RESULTS:
There were high statistically significant increases in the number of cases with factor V, prothrombin, and methylenetetrahydrofolate reductase gene mutations compared with normal control and the percentage of multiple gene mutations was higher than single gene mutation.
CONCLUSION:
The prevalence of thrombophilic mutations is higher in cases of RSM than control.