Psychogenic nonepileptic seizures (PNES) account for 10-40% of patients diagnosed epileptic seizures. Distinguishing between psychogenic nonepileptic seizures and epileptic one is a very difficult task. Aim of this study is to estimate the presence of PNES in a previously diagnosed epileptic seizures (ES) by evidence based tools with detection of psychiatric comorbidity and some related etiological factors. Methodology: This study included 75 patients referred as epileptics. All patients were subjected to a detailed neuropsychiatric examination, Present State Examination (PSE), Toronto Alexithymia Scales (TAS-20), Eysenck Personality Inventory, Middlesex scale, basal and postictal prolactin level, CT brain, video-records, routine EEG. The comparative study included: demographic data, seizure semiology, and psychiatric comorbidity. Results: 20 patients (26.66%) diagnosed as PNES, 52 patients (69.33%) diagnosed as epilepsy and 3 patients (3.68%) diagnosed as epilepsy plus PNES. Depression (50%), anxiety (50%), somatoform disorders (30%) and other dissociative disorders (40%) are the commonest psychiatric comorbidities in PNES. Conclusion: This study shed light on misdiagnosis of PNES patients and consequences of this problem.