Staff Members - Benha University
Cross talk between oxidative stress and inflammation in alopecia areata.
Journal of Cosmetic Dermatology • 2021
Publication Information
Authors
Mustafa, A.I., Khashaba, R.A., Fawzy, E., Baghdady, S.M.A. and Rezk, S.M.
Keywords
8-OHdG, Alopecia areata, CRP, HMGB1, Oxidative stress
Journal
Journal of Cosmetic Dermatology
Publisher
Wiley Online Library
Volume
20
Issue
7
Pages
2305-2310
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031,
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031,