| publication name | Cross talk between oxidative stress and inflammation in alopecia areata. |
|---|---|
| Authors | Mustafa, A.I., Khashaba, R.A., Fawzy, E., Baghdady, S.M.A. and Rezk, S.M. |
| year | 2021 |
| keywords | 8-OHdG, Alopecia areata, CRP, HMGB1, Oxidative stress |
| journal | Journal of Cosmetic Dermatology |
| volume | 20 |
| issue | 7 |
| pages | 2305-2310 |
| publisher | Wiley Online Library |
| Local/International | International |
| Paper Link | https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13814 |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C-reactive protein (CRP). Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP. Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031,