Staff Members - Benha University
Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case– Control Study
American Journal of Perinatology • 2021
Publication Information
Authors
Shaimaa Reda Abdelmaksoud; Mostafa Abdel-Azim Mostafa; Rana Atef khashaba; Effat Assar
Keywords
25-OH vitamin D; late-onset neonatal sepsis; neonatal sepsis
Journal
American Journal of Perinatology
Publisher
Thieme
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Objective The aim of the study is to investigate the relation of neonatal andmaternal
vitamin D and late-onset sepsis (LOS)
Study Design One-hundred twenty term neonates along with their mothers were
enrolled in this case–control study. Sixty neonates who were admitted in the neonatal
intensive care unit by LOS and had not been previously admitted for last 48 hours and
did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the
other hand, 60 healthy term neonates were referred as control group. Maternal and
neonatal serum 25-OH vitamin D levels were assessed in both the cohorts.
Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL,
respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively)
p¼0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated
with C-reactive protein and length of hospital stay (r¼0.616 and 0.596, respectively)
p
vitamin D and late-onset sepsis (LOS)
Study Design One-hundred twenty term neonates along with their mothers were
enrolled in this case–control study. Sixty neonates who were admitted in the neonatal
intensive care unit by LOS and had not been previously admitted for last 48 hours and
did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the
other hand, 60 healthy term neonates were referred as control group. Maternal and
neonatal serum 25-OH vitamin D levels were assessed in both the cohorts.
Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL,
respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively)
p¼0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated
with C-reactive protein and length of hospital stay (r¼0.616 and 0.596, respectively)
p