Background: Trans-thoracic Ultrasonography is a well-known technique in the evaluation of thoracic disorders especially peripheral lung lesions. This study aimed at assessing the diagnostic yield of percutaneous ultrasound-guided biopsy in the diagnosis of peripheral lung lesions. Patients and Methods: A 50 patients (38 males, 12 females) all have peripheral lung lesion underwent US-guided core biopsy using 3.5 - 5Hz Curvilinear probe to allow the availability of histopathological findings. Results: Final diagnosis was 34 malignant cases and 15 cases with non-malignant lesions and 1 case with no diagnosis. US examination showed hypoechoic lesions in 38 cases (76%) which formed 91% of malignant cases and also revealed 29 cases (58%) with lesions with internal echoes inside, which constituted 100% of non-malignant cases with significant difference between malignant and nonmalignant. US-guided biopsy was diagnostic in 48 patients out of 50 (96%). Two cases only complicated with pneumothorax (4%), one case of moderate hemoptysis, and other non-serious complications like chest pain and mild self-limited hemoptysis were found in11 cases. Conclusion: Ultrasonography is a non- invasive, and promising bedside diagnostic tool for examination of patients with peripheral lung lesions and weak role in deeper lung lesion.