Staff Members - Benha University
Beneficial effect of probiotics on antioxidants and Oxidative Stress in experimental induced Non Alcoholic Fatty Liver Disease in Rats
Intternattiionall Journall of Chemiicall and Natturall Sciience • 2017
Publication Information
Authors
Omayma A.R. Abou Zaid, Omnia M. AbdEl-hamid and Shimaa Ahmed El-Refaey Atwa
Keywords
Not Available
Journal
Intternattiionall Journall of Chemiicall and Natturall Sciience
Publisher
Not Available
Volume
5,
Issue
3
Pages
543-547
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
The main objective of this study to investigate the Beneficial effect of probiotics on Oxidative Stress in experimental
induced Nonalcoholic fatty liver disease [ NAFLD] in rats . Thirty male albino rats were divided into three groups [10
rats each]. The first group fed a normal diet and represents the control group. The second group [NAFLD] fed
normal diet enriched with1% cholesterol and 2% coconut oil and act as positive group [+ve control]. The third
group fed on normal diet enriched with1% cholesterol and 2% coconut oil and probiotics [BIO-BC™]at a dose of 1-
2g/liter at a rat dose [0.5-1ml/kg. body. Weight] orally . Samples collected after 2,4and6 weeks after induction
from treatment. serum was collected for estimation of Serum Nitric Oxide [ NO], Serum L- Malonialdehyde [L-MDA]
and Tissues as liver [Enzymatic Antioxidants as [Liver Catalase [ L-CAT, Liver superoxide dismutase [L-SOD] ,Non
Enzymatic Antioxidants as Liver Reduced Glutathione [L-GSH]. Our results revealed a significant decrease in serum
NO, L-CAT, L-SOD, L-GSH moreover serum L-MDA. The behavioural biochemical results indicated treatment with
probiotics showed significant changes and improves these parameters.
induced Nonalcoholic fatty liver disease [ NAFLD] in rats . Thirty male albino rats were divided into three groups [10
rats each]. The first group fed a normal diet and represents the control group. The second group [NAFLD] fed
normal diet enriched with1% cholesterol and 2% coconut oil and act as positive group [+ve control]. The third
group fed on normal diet enriched with1% cholesterol and 2% coconut oil and probiotics [BIO-BC™]at a dose of 1-
2g/liter at a rat dose [0.5-1ml/kg. body. Weight] orally . Samples collected after 2,4and6 weeks after induction
from treatment. serum was collected for estimation of Serum Nitric Oxide [ NO], Serum L- Malonialdehyde [L-MDA]
and Tissues as liver [Enzymatic Antioxidants as [Liver Catalase [ L-CAT, Liver superoxide dismutase [L-SOD] ,Non
Enzymatic Antioxidants as Liver Reduced Glutathione [L-GSH]. Our results revealed a significant decrease in serum
NO, L-CAT, L-SOD, L-GSH moreover serum L-MDA. The behavioural biochemical results indicated treatment with
probiotics showed significant changes and improves these parameters.