Abstract: In KSA, non-communicable diseases are estimated to account for 71% of all deaths. Point-of-care testing (PoCT) provides timely information to medical teams to improve patient outcomes in critical care settings. Aim of this study: to diagnose chronic disease in early stage and validate the Reflotron plus in detection of these diseases. Subject and methods: A cross sectional survey included 200 participants randomly selected from governmental institutions in Northern borders region from both sexes aged from 30-40 years old. Results: 27% of samples had elevated blood glucose level, lipid profile showed that 21% for Cholesterol, 12% for TG and 30.5% for LDL, 26% had raised blood pressure, 22% were classified as being obese, the sensitivity in DM, Cholesterol, TG and LDL was 92.6%, 90.5%, 91.7% and 90% respectively, while Specificity was 95.9%, 87.9%, 94.02% and 89.9% respectively. Conclusion: non-communicable diseases represents a major clinical and public health problem in northern borders region. Reflotron plus is good as screening test.