Background: Recurrence of cancer breast is a major problem during the first
2 years after diagnosis in addition to selection of adjuvant regimen is based
mainly on the axillary lymph nodes stage. So, cost-effectively, patient will save
much amount of budget needed for detection of gene expression. This study
evaluates axillary lymph nodes dissection in prognosis of HER2-positive breast
cancer.
Patients and methods: The current study analyzed 100 patients complained
breast cancer. There were two types of surgery performed; MRM in 46 cases
(46%) when there were con traindications of BCT or patients preferred radical
surgery and BCT in 54 cases (54%) when indicated. Follow-up was for 2 years.
Results: All cases passed operation without mortality. Recurrence was
reported in ten patients (10%). Six patients (6%) died during their follow up
due to distant metastasis. All recurrent patients having grade N3 >9 positive
lymph nodes; P-value; 0.0001. There was statistical significance between
nodal status and tumor size; KW test & P; 8.08 & 0.044 (S) respectively and
between Histopathology and Nodal status; FET & P; 5.96 & 0.031 (S)
respectively.
Conclusion: Positive or negative axillary lymph nodes are
considered the most important predicting factor for recurrence and
overall survival of HER2-positive patients complained breast
cancer. Moreover worsening prognosis is closely related to which
group positive and the number of affected lymph nodes.