Severe Left Ventricular Dysfunction Earlier after Acute Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention: Predictors and In-Hospital Outcome– A Middle Eastern Tertiary Center Experience
Journal of Saudi Heart Association • 2023
Publication Information
Authors
Sheeren Khaled,Ghada Shalaby
Keywords
Myocardial infarction, Left ventricular dysfunction, Primary percutaneous coronary intervention
Journal
Journal of Saudi Heart Association
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
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Abstract
Improving or maintaining heart function following percutaneous coronary intervention (PPCI) is not identified in all
patients. Our aim in the current study is to investigate the prevalence, factors associated with early left ventricular (LV)
dysfunction following successful revascularization of myocardial infarction patients.
Methods: A single-center retrospective study included 2863 myocardial infarction patients who were admitted to our
center and treated with successful PPCI.
Results: Out of 2863 consecutive patientswhounderwent PPCI fromMay2018 toAugust 2021, 1021 (36%) developed server
LV dysfunction. They showed a higher history rate of ischemic heart disease and previous revascularization before AMI
(P ¼ 0.05 and 0.001 respectively). Also, they presented more with anterior myocardial infarction (P < 0.001) and heavy
thrombus burden (P ¼ 0.002 and 0.004 for indication of peri-procedural glycoprotein IIb/IIIa inhibitors use and thrombus
aspiration) compared to the other group of patients. Moreover, they also had a more critical anatomy of coronary artery
disease (P < 0.001 for both left main and multi-vessel coronary artery disease). The independently associated predictors for
early severe LV dysfunction post-AMI treated with PPCI were anterior localization of AMI, the greater value of troponin,
renal impairment, and severe coronary artery disease (P¼
patients. Our aim in the current study is to investigate the prevalence, factors associated with early left ventricular (LV)
dysfunction following successful revascularization of myocardial infarction patients.
Methods: A single-center retrospective study included 2863 myocardial infarction patients who were admitted to our
center and treated with successful PPCI.
Results: Out of 2863 consecutive patientswhounderwent PPCI fromMay2018 toAugust 2021, 1021 (36%) developed server
LV dysfunction. They showed a higher history rate of ischemic heart disease and previous revascularization before AMI
(P ¼ 0.05 and 0.001 respectively). Also, they presented more with anterior myocardial infarction (P < 0.001) and heavy
thrombus burden (P ¼ 0.002 and 0.004 for indication of peri-procedural glycoprotein IIb/IIIa inhibitors use and thrombus
aspiration) compared to the other group of patients. Moreover, they also had a more critical anatomy of coronary artery
disease (P < 0.001 for both left main and multi-vessel coronary artery disease). The independently associated predictors for
early severe LV dysfunction post-AMI treated with PPCI were anterior localization of AMI, the greater value of troponin,
renal impairment, and severe coronary artery disease (P¼
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